Figures
LocaNMF for region-based decomposition of neural recordings from the mouse brain
Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex. Saxena et al. developed LocaNMF (Localized semi-Nonnegative Matrix Factorization), allowing the decomposition of the recorded data into interpretable spatial and temporal components in a stable manner. This is done by mapping the inferred components onto well-defined brain regions using a widely-used brain atlas (here, the Allen Brain Atlas shown in black lines). Each color in this figure corresponds to a given region's spatial components in this mouse brain. Data collected by Simon Musall in the Churchland Laboratory at Cold Spring Harbor Laboratory.
Image Credit: Shreya Saxena, Columbia University
Citation: (2020) PLoS Computational Biology Issue Image | Vol. 16(4) May 2020. PLoS Comput Biol 16(4): ev16.i04. https://doi.org/10.1371/image.pcbi.v16.i04
Published: May 1, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex. Saxena et al. developed LocaNMF (Localized semi-Nonnegative Matrix Factorization), allowing the decomposition of the recorded data into interpretable spatial and temporal components in a stable manner. This is done by mapping the inferred components onto well-defined brain regions using a widely-used brain atlas (here, the Allen Brain Atlas shown in black lines). Each color in this figure corresponds to a given region's spatial components in this mouse brain. Data collected by Simon Musall in the Churchland Laboratory at Cold Spring Harbor Laboratory.
Image Credit: Shreya Saxena, Columbia University