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PLoS Computational Biology Issue Image | Vol. 16(4) May 2020

PLoS Computational Biology Issue Image | Vol. 16(4) May 2020

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LocaNMF for region-based decomposition of neural recordings from the mouse brain

Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex. Saxena et al. developed LocaNMF (Localized semi-Nonnegative Matrix Factorization), allowing the decomposition of the recorded data into interpretable spatial and temporal components in a stable manner. This is done by mapping the inferred components onto well-defined brain regions using a widely-used brain atlas (here, the Allen Brain Atlas shown in black lines). Each color in this figure corresponds to a given region's spatial components in this mouse brain. Data collected by Simon Musall in the Churchland Laboratory at Cold Spring Harbor Laboratory.

Image Credit: Shreya Saxena, Columbia University

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LocaNMF for region-based decomposition of neural recordings from the mouse brain

Widefield calcium imaging provides a global view of neural activity in the mouse dorsal cortex. Saxena et al. developed LocaNMF (Localized semi-Nonnegative Matrix Factorization), allowing the decomposition of the recorded data into interpretable spatial and temporal components in a stable manner. This is done by mapping the inferred components onto well-defined brain regions using a widely-used brain atlas (here, the Allen Brain Atlas shown in black lines). Each color in this figure corresponds to a given region's spatial components in this mouse brain. Data collected by Simon Musall in the Churchland Laboratory at Cold Spring Harbor Laboratory.

Image Credit: Shreya Saxena, Columbia University

https://doi.org/10.1371/image.pcbi.v16.i04.g001