Figures
Spatial dependencies between influenza virus vRNPs.
In influenza virus infected cells, eight viral genomic RNPs are assembled into progeny virions, which predominantly contain one copy of each. Using sets of fluorescence microscope images of four vRNPs, the likelihood that the subcellular distribution of one vRNP can be predicted from the distribution of another was estimated for all pairs of vRNPs with significant relationships. The thick base of the bands indicates the vRNP whose location can be used to predict the location of the vRNP indicated by the thin base. These pairwise and higher order relationships were used to infer the assembly network for all eight vRNPs.
Image Credit: Timothy D. Majarian, Robert F. Murphy and Seema S. Lakdawala. © 2018, Carnegie Mellon University
Citation: (2019) PLoS Computational Biology Issue Image | Vol. 15(1) January 2019. PLoS Comput Biol 15(1): ev15.i01. https://doi.org/10.1371/image.pcbi.v15.i01
Published: January 31, 2019
Copyright: © 2019 Majarian, Murphy and Lakdawala. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In influenza virus infected cells, eight viral genomic RNPs are assembled into progeny virions, which predominantly contain one copy of each. Using sets of fluorescence microscope images of four vRNPs, the likelihood that the subcellular distribution of one vRNP can be predicted from the distribution of another was estimated for all pairs of vRNPs with significant relationships. The thick base of the bands indicates the vRNP whose location can be used to predict the location of the vRNP indicated by the thin base. These pairwise and higher order relationships were used to infer the assembly network for all eight vRNPs.
Image Credit: Timothy D. Majarian, Robert F. Murphy and Seema S. Lakdawala. © 2018, Carnegie Mellon University