Figures
Considering cellular metabolism within a whole-body context.
Integrating metabolic networks at the cellular scale into physiologically based pharmacokinetic models at the organism level allows the mechanistic description of drug action, pathogenesis, or adverse events across multiple layers of biological organization. Such multiscale approaches therefore provide the opportunity for novel rational approaches in medical diagnostics and pharmaceutical drug development. The figure illustrates a schematic overview of the approach used in Krauss et al.
Image Credit: Stephan Schaller, Markus Krauss, and Lars Kuepfer.
Citation: (2012) PLoS Computational Biology Issue Image | Vol. 8(10) October 2012. PLoS Comput Biol 8(10): ev08.i10. https://doi.org/10.1371/image.pcbi.v08.i10
Published: October 25, 2012
Copyright: © 2012 Schaller et al. . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Integrating metabolic networks at the cellular scale into physiologically based pharmacokinetic models at the organism level allows the mechanistic description of drug action, pathogenesis, or adverse events across multiple layers of biological organization. Such multiscale approaches therefore provide the opportunity for novel rational approaches in medical diagnostics and pharmaceutical drug development. The figure illustrates a schematic overview of the approach used in Krauss et al.
Image Credit: Stephan Schaller, Markus Krauss, and Lars Kuepfer.