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PLoS Computational Biology Issue Image | Vol. 6(11) November 2010

PLoS Computational Biology Issue Image | Vol. 6(11) November 2010

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Biology of the microtubule-associated protein tau.

The phosphoprotein tau is normally bound to microtubules. However, tau that is abnormally phosphorylated dissociates from microtubules. Accumulated soluble tau molecules then misfold and aggregate. These aggregations are a hallmark of the tauopathies responsible for cognitive dysfunction and neuropathies such as Alzheimer's disease (see Yuraszeck et al. doi:10.1371/journal.pcbi.1000997).

Image Credit: Peter Allen

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Biology of the microtubule-associated protein tau.

The phosphoprotein tau is normally bound to microtubules. However, tau that is abnormally phosphorylated dissociates from microtubules. Accumulated soluble tau molecules then misfold and aggregate. These aggregations are a hallmark of the tauopathies responsible for cognitive dysfunction and neuropathies such as Alzheimer's disease (see Yuraszeck et al. doi:10.1371/journal.pcbi.1000997).

Image Credit: Peter Allen

https://doi.org/10.1371/image.pcbi.v06.i11.g001