Amino Acid Conservation Scores ======================================= - POS: The position of the AA in the SEQRES derived sequence. - SEQ: The SEQRES derived sequence in one letter code. - 3LATOM: The ATOM derived sequence in three letter code, including the AA's positions as they appear in the PDB file and the chain identifier. - SCORE: The normalized conservation scores. - COLOR: The color scale representing the conservation scores (9 - conserved, 1 - variable). - CONFIDENCE INTERVAL: When using the bayesian method for calculating rates, a confidence interval is assigned to each of the inferred evolutionary conservation scores. - CONFIDENCE INTERVAL COLORS: When using the bayesian method for calculating rates. The color scale representing the lower and upper bounds of the confidence interval. - MSA DATA: The number of aligned sequences having an amino acid (non-gapped) from the overall number of sequences at each position. - RESIDUE VARIETY: The residues variety at each position of the multiple sequence alignment. POS SEQ 3LATOM SCORE COLOR CONFIDENCE INTERVAL CONFIDENCE INTERVAL COLORS MSA DATA RESIDUE VARIETY (normalized) 1 G GLY0:A -0.326 6* -1.062, 0.187 8,4 1/137 G 2 M MET1:A -1.357 9 -1.574,-1.282 9,9 57/137 M 3 T THR2:A 0.846 2 0.322, 1.185 4,1 62/137 D,M,I,T,E,N,S,A 4 D ASP3:A -0.181 6 -0.532, 0.068 7,5 64/137 S,D,G,X,E,T 5 C CYS4:A 2.779 1 1.640, 2.803 1,1 69/137 R,Y,M,D,P,G,Q,H,A,S,C,L,N,T 6 E GLU5:A -0.834 8 -1.116,-0.662 8,7 69/137 E,V,N,D 7 F PHE6:A -0.584 7 -0.953,-0.310 8,6 69/137 L,F,S 8 G GLY7:A 2.590 1 1.640, 2.803 1,1 69/137 T,E,N,F,L,C,S,A,H,W,G,M,Y,I,R 9 Y TYR8:A 0.662 3* 0.068, 1.185 5,1 71/137 Y,H,F,L,S 10 I ILE9:A 0.082 5 -0.310, 0.322 6,4 71/137 A,I,V,T 11 Y TYR10:A 0.716 3 0.187, 1.185 4,1 72/137 R,Y,V,H,Q,S,C,L,N 12 R ARG11:A 2.329 1 1.185, 2.803 1,1 73/137 K,A,S,L,C,N,E,T,R,Y,M,G,X,V 13 L LEU12:A -1.335 9 -1.574,-1.282 9,9 74/137 L 14 A ALA13:A -0.727 7 -1.007,-0.532 8,7 74/137 V,T,I,A 15 Q GLN14:A -0.308 6 -0.662,-0.038 7,5 74/137 E,L,K,Q,R 16 D ASP15:A -1.067 8 -1.282,-0.953 9,8 74/137 H,G,D,E 17 Y TYR16:A -1.317 9 -1.574,-1.225 9,9 74/137 Y 18 L LEU17:A -0.815 7 -1.116,-0.662 8,7 76/137 V,T,M,I,L 19 Q GLN18:A 1.912 1 0.884, 2.803 2,1 76/137 T,E,L,C,S,K,Q,D,R 20 C CYS19:A 1.111 2 0.475, 1.640 4,1 76/137 C,L,F,D,Y,K,H 21 V VAL20:A -0.813 7 -1.062,-0.662 8,7 76/137 V,T,A,I,C 22 L LEU21:A -0.235 6 -0.598, 0.068 7,5 78/137 L,G,C,R,I,Q,W 23 Q GLN22:A -0.060 5 -0.388, 0.187 6,4 81/137 N,E,T,Q,K,L,R,D,P 24 I ILE23:A 1.613 1 0.884, 1.640 2,1 93/137 P,G,M,I,R,V,L,S,A,Q,T,E,N 25 P PRO24:A -0.140 5 -0.462, 0.068 6,5 95/137 G,P,S,A,R,Q,T 26 Q GLN25:A 1.289 1 0.659, 1.640 3,1 90/137 H,Q,A,K,S,L,N,E,T,R,M,G,P 27 P PRO26:A 2.446 1 1.185, 2.803 1,1 90/137 V,R,P,G,D,E,A,Q,L,C,F,S 28 G GLY27:A 2.473 1 1.185, 2.803 1,1 90/137 V,P,G,R,E,T,N,S,C,H,A,K 29 S SER28:A 1.381 1 0.659, 1.640 3,1 87/137 G,P,M,I,W,V,L,S,A,T,E 30 G GLY29:A 1.127 2 0.475, 1.640 4,1 88/137 N,T,E,K,A,Q,H,C,L,S,V,R,P,G 31 P PRO30:A 0.817 3 0.322, 1.185 4,1 98/137 V,I,M,G,P,N,E,T,H,Q,A,S,L 32 S SER31:A -0.285 6 -0.532,-0.137 7,5 106/137 G,D,I,R,T,E,N,S,K,A,H,Q 33 K LYS32:A 0.828 2 0.322, 1.185 4,1 106/137 V,R,P,D,T,E,A,K,H,Q,L,C,S 34 T THR33:A -0.131 5 -0.388, 0.068 6,5 107/137 V,T,I,A,S,F,L 35 S SER34:A -0.494 7 -0.724,-0.388 7,6 108/137 Q,H,K,A,S,C,L,F,E,R,G,V 36 R ARG35:A 0.560 3 0.187, 0.884 4,2 108/137 G,R,E,N,L,C,S,A,K,Q,H 37 V VAL36:A 0.045 5 -0.310, 0.187 6,4 108/137 H,Q,K,A,S,C,L,N,T,I,V 38 L LEU37:A -1.061 8 -1.225,-0.953 9,8 110/137 M,I,L 39 Q GLN38:A -0.674 7 -0.897,-0.532 8,7 112/137 L,K,A,I,Q,R,X 40 N ASN39:A 1.141 2 0.659, 1.640 3,1 115/137 A,K,Q,H,F,S,N,T,E,M,R,G,D,V 41 V VAL40:A -0.526 7 -0.724,-0.388 7,6 120/137 S,L,I,A,M,T,V 42 A ALA41:A -0.672 7 -0.897,-0.532 8,7 122/137 V,G,M,T,S,C,H,A 43 F PHE42:A -0.394 6 -0.662,-0.226 7,6 124/137 N,E,T,Q,A,K,S,F,L,W,D 44 S SER43:A -0.570 7 -0.783,-0.462 7,6 128/137 R,D,G,E,Q,H,A,S,F,L 45 V VAL44:A -0.374 6 -0.598,-0.226 7,6 128/137 V,L,F,Y,M,A,I 46 Q GLN45:A -0.765 7 -0.953,-0.662 8,7 128/137 I,M,D,N,E,Q,H,S,L 47 K LYS46:A 1.750 1 0.884, 1.640 2,1 130/137 R,D,G,Q,K,A,S,L,N,E,T 48 E GLU47:A -0.007 5 -0.310, 0.187 6,4 103/137 D,R,S,K,Q,T,E,N 49 V VAL48:A -0.900 8 -1.062,-0.783 8,7 104/137 F,H,A,T,N,R,Y,V 50 E GLU49:A -0.398 6 -0.662,-0.226 7,6 130/137 G,P,D,R,E,N,L,S,K,A,H,Q 51 K LYS50:A 2.039 1 1.185, 2.803 1,1 130/137 I,R,D,G,V,Q,A,C,L,T,Y,M,P,H,K,S,N,E 52 N ASN51:A 1.064 2 0.659, 1.185 3,1 133/137 H,Q,A,K,S,F,L,N,E,T,I,R,D,V 53 L LEU52:A -0.652 7 -0.897,-0.532 8,7 135/137 F,L,Y,M,I,V 54 K LYS53:A 0.142 5 -0.137, 0.322 5,4 136/137 D,R,E,T,N,S,C,L,H,Q,A,K 55 S SER54:A 0.602 3 0.187, 0.884 4,2 136/137 R,G,P,D,N,T,E,A,H,Q,C,L,S 56 C CYS55:A 0.159 5 -0.137, 0.322 5,4 136/137 Y,M,I,W,V,F,C,L,S,A 57 L LEU56:A -0.510 7 -0.724,-0.388 7,6 136/137 V,M,R,I,T,C,F,L,S,A 58 D ASP57:A 0.071 5 -0.226, 0.187 6,4 136/137 E,T,N,S,L,Q,H,A,K,D,G,R,Y 59 N ASN58:A 1.001 2 0.475, 1.185 4,1 136/137 N,T,E,K,A,H,Q,L,S,Y,R,G,D 60 V VAL59:A 0.008 5 -0.310, 0.187 6,4 136/137 Q,L,C,F,S,T,M,I,P,V,W 61 N ASN60:A 0.502 3 0.068, 0.659 5,3 113/137 V,R,G,P,D,N,E,K,A,H,Q,L,S 62 V VAL61:A -0.115 5 -0.388, 0.068 6,5 113/137 W,V,P,I,R,M,L,F,C,Q 63 V VAL62:A 1.735 1 0.884, 2.803 2,1 78/137 R,I,M,D,G,V,Q,H,A,S,E,T 64 S SER63:A -0.511 7 -0.724,-0.388 7,6 136/137 L,C,S,A,Q,T,E,N,P,G,D,R,V 65 V VAL64:A 1.186 1 0.659, 1.640 3,1 136/137 P,M,E,N,F,S,K,H,V,G,D,I,R,T,L,C,A,Q 66 D ASP65:A 1.502 1 0.884, 1.640 2,1 136/137 P,G,D,I,R,V,C,S,A,K,Q,T,E,N 67 T THR66:A 0.333 4 -0.038, 0.475 5,4 136/137 K,S,N,E,M,P,Q,A,L,C,T,R,I,D,G,V 68 A ALA67:A -0.953 8 -1.116,-0.841 8,8 136/137 P,D,M,S,K,A,T,E 69 R ARG68:A 0.384 4 0.068, 0.659 5,3 137/137 M,Y,R,I,V,W,K,H,Q,C,L,F,S,N,E 70 T THR69:A 1.280 1 0.659, 1.640 3,1 137/137 V,P,G,D,M,I,R,T,E,N,S,A,K,H,Q 71 L LEU70:A -0.410 6 -0.598,-0.310 7,6 137/137 S,L,F,A,K,T,N,G,I,R,M,V 72 F PHE71:A -1.180 9 -1.343,-1.116 9,8 137/137 V,Y,M,L,F 73 N ASN72:A 1.167 1 0.659, 1.640 3,1 137/137 E,N,S,F,H,K,P,M,Y,T,C,L,Q,A,V,D,G,R,I 74 Q GLN73:A 0.337 4 -0.038, 0.475 5,4 137/137 V,I,R,D,G,N,E,T,Q,K,A,S 75 V VAL74:A -1.366 9 -1.496,-1.343 9,9 137/137 V,I,L 76 M MET75:A -0.992 8 -1.170,-0.897 9,8 137/137 T,L,C,S,A,V,M,I 77 E GLU76:A 0.643 3 0.187, 0.884 4,2 137/137 K,S,N,E,Y,M,A,Q,L,C,T,I,R,G,D,V 78 K LYS77:A 0.123 5 -0.226, 0.322 6,4 137/137 M,R,G,K,H,Q,S,N,T,E 79 E GLU78:A -0.899 8 -1.062,-0.783 8,7 137/137 E,V,L,K,M,I 80 F PHE79:A -1.120 8 -1.282,-1.007 9,8 137/137 Y,I,L,F,V 81 E GLU80:A 0.030 5 -0.226, 0.187 6,4 137/137 D,G,R,I,V,S,Q,K,A,E,T,N 82 D ASP81:A -1.074 8 -1.225,-1.007 9,8 137/137 T,E,N,S,A,Q,H,G,D 83 G GLY82:A -1.238 9 -1.410,-1.170 9,9 137/137 N,G,D,Q 84 I ILE83:A 0.765 3 0.322, 1.185 4,1 101/137 E,T,N,H,Q,K,V,P,R,I 85 I ILE84:A -0.143 5 -0.388, 0.068 6,5 137/137 D,Y,M,I,V,L,F,C,K,T 86 N ASN85:A -1.371 9 -1.496,-1.343 9,9 136/137 T,X,N,R 87 W TRP86:A -1.390 9 -1.574,-1.343 9,9 137/137 W 88 G GLY87:A -1.375 9 -1.574,-1.343 9,9 137/137 E,G,A 89 R ARG88:A -1.472 9 -1.574,-1.496 9,9 137/137 K,R 90 I ILE89:A -1.053 8 -1.225,-0.953 9,8 137/137 I,L,V 91 V VAL90:A -1.266 9 -1.410,-1.225 9,9 137/137 V,M,A,I,L 92 T THR91:A -1.153 9 -1.282,-1.062 9,8 137/137 A,G,S,V,T 93 I ILE92:A -0.564 7 -0.783,-0.462 7,6 137/137 F,L,I,M,V 94 F PHE93:A -0.832 8 -1.062,-0.724 8,7 137/137 V,Y,I,F,L 95 A ALA94:A -0.683 7 -0.897,-0.532 8,7 137/137 V,Y,M,G,E,T,H,A,S,L,C,F 96 F PHE95:A -1.190 9 -1.343,-1.116 9,8 137/137 L,F,V 97 E GLU96:A -0.600 7 -0.841,-0.462 8,6 137/137 T,E,G,C,S,A,Q 98 G GLY97:A -0.666 7 -0.897,-0.532 8,7 137/137 S,C,F,G,A,Y 99 I ILE98:A -0.204 6 -0.462,-0.038 6,5 137/137 T,F,C,L,S,A,K,Q,V,M,R,I 100 L LEU99:A -0.761 7 -0.953,-0.598 8,7 137/137 F,L,M,I,V 101 I ILE100:A -0.188 6 -0.462,-0.038 6,5 137/137 M,I,V,A,L,C,S,N,T 102 K LYS101:A -0.195 6 -0.462,-0.038 6,5 137/137 V,Y,R,I,N,F,L,S,A,K,H,Q 103 K LYS102:A 0.079 5 -0.226, 0.322 6,4 137/137 R,Y,D,N,E,Q,H,A,K,S,F,L 104 L LEU103:A -0.743 7 -0.953,-0.598 8,7 136/137 S,C,F,L,H,A,T,N,M,V 105 L LEU104:A 0.094 5 -0.226, 0.322 6,4 136/137 I,R,Y,M,P,V,Q,A,K,S,C,F,L,T 106 R ARG105:A 1.036 2 0.475, 1.185 4,1 134/137 E,T,N,S,C,Q,K,V,D,G,P,I,R,M 107 Q GLN106:A 0.807 3 0.322, 1.185 4,1 133/137 N,T,E,K,A,H,Q,S,R,I,G,D 108 Q GLN107:A 0.953 2 0.475, 1.185 4,1 131/137 D,G,P,R,E,T,N,S,L,C,H,Q,K,A 109 I ILE108:A 1.162 1 0.475, 1.640 4,1 73/137 A,S,L,T,I,R,M,D,G,V 110 A ALA109:A 0.622 3 0.187, 0.884 4,2 76/137 C,S,A,Q,T,N,P,G,D,R,I,V 111 P PRO110:A 1.417 1 0.659, 1.640 3,1 75/137 L,S,A,K,H,P,M,I,R 112 D ASP111:A -0.008 5 -0.310, 0.187 6,4 129/137 T,E,N,L,S,A,K,Q,H,V,G,D,M,R,I 113 V VAL112:A 1.607 1 0.884, 1.640 2,1 134/137 T,A,Q,L,C,V,R,I,G,D,N,E,K,H,F,S,M,Y,P 114 D ASP113:A 1.140 2 0.659, 1.640 3,1 135/137 D,G,P,R,Y,V,S,H,Q,K,A,E,T,N 115 T THR114:A 0.582 3 0.187, 0.884 4,2 134/137 G,D,R,I,V,L,C,A,Q,T,P,M,Y,F,S,H,E,N 116 Y TYR115:A 0.120 5 -0.226, 0.322 6,4 130/137 P,Y,F,S,K,H,E,N,D,I,R,V,C,L,A,Q 117 K LYS116:A 0.872 2 0.475, 1.185 4,1 134/137 S,Q,H,A,K,E,T,N,D,G,R,M 118 E GLU117:A 1.058 2 0.659, 1.185 3,1 131/137 N,E,T,H,Q,K,A,S,L,C,R,M,D,G,P 119 I ILE118:A -0.892 8 -1.062,-0.783 8,7 134/137 V,I,F,L 120 S SER119:A -0.725 7 -0.897,-0.598 8,7 134/137 G,P,I,M,V,S,F,C,L,A,E,T 121 Y TYR120:A 1.728 1 0.884, 1.640 2,1 134/137 Y,K,H,F,S,N,E,R,I,G,D,V,A,Q,L,C,T 122 F PHE121:A -0.210 6 -0.532,-0.038 7,5 134/137 K,L,C,F,E,T,I,Y,W 123 V VAL122:A -0.468 6 -0.662,-0.310 7,6 134/137 A,L,F,S,T,M,I,V 124 A ALA123:A -0.723 7 -0.897,-0.598 8,7 134/137 L,S,A,T,P,G,M,I,V 125 E GLU124:A -0.115 5 -0.388, 0.068 6,5 134/137 L,S,A,K,Q,H,T,E,N,D,M,R,V 126 F PHE125:A -0.776 7 -1.007,-0.662 8,7 134/137 V,H,A,Y,F 127 I ILE126:A -0.801 7 -1.007,-0.662 8,7 134/137 T,V,S,L,F,I,M 128 M MET127:A 1.309 1 0.884, 1.640 2,1 130/137 W,M,Y,E,N,S,K,V,G,D,R,I,T,C,L,A,Q 129 N ASN128:A 1.075 2 0.659, 1.185 3,1 134/137 S,K,A,Q,H,T,E,N,G,D,R 130 N ASN129:A 0.679 3 0.322, 0.884 4,2 134/137 E,T,N,S,L,Q,H,K,P,G,R,I,Y 131 T THR130:A -0.369 6 -0.598,-0.226 7,6 134/137 V,I,M,T,C,L,Q,A,K 132 G GLY131:A 0.334 4 -0.038, 0.475 5,4 134/137 D,G,R,I,Y,V,S,L,H,Q,A,K,E,T 133 E GLU132:A 1.153 1 0.659, 1.640 3,1 134/137 F,L,S,K,A,Q,H,T,E,N,G,P,D,R 134 W TRP133:A -1.389 9 -1.574,-1.343 9,9 134/137 W 135 I ILE134:A -1.287 9 -1.410,-1.225 9,9 134/137 I,M,L,V 136 R ARG135:A 0.593 3 0.187, 0.884 4,2 134/137 C,L,S,K,A,Q,T,E,N,D,M,R,I,V 137 Q GLN136:A -0.345 6 -0.598,-0.226 7,6 134/137 D,R,T,E,L,S,A,K,Q,H 138 N ASN137:A -0.858 8 -1.007,-0.783 8,7 134/137 N,H,R,Q,S 139 G GLY138:A -1.321 9 -1.496,-1.282 9,9 134/137 N,G,D,R 140 G GLY139:A -1.313 9 -1.496,-1.225 9,9 134/137 D,S,G,A 141 W TRP140:A -1.389 9 -1.574,-1.343 9,9 134/137 W 142 E GLU141:A 0.354 4 -0.038, 0.659 5,3 128/137 N,E,K,Q,L,S,V,I,R,P,G,D 143 N ASN142:A -0.549 7 -0.841,-0.388 8,6 65/137 K,R,H,P,D,N 144 G GLY143:A -0.845 8 -1.062,-0.724 8,7 118/137 N,T,R,A,S,G,C 145 F PHE144:A -1.008 8 -1.225,-0.897 9,8 94/137 A,I,F,L,T 146 V VAL145:A -0.043 5 -0.388, 0.187 6,4 92/137 T,S,F,C,L,A,V,D,I,M 147 K LYS146:A 0.146 5 -0.226, 0.322 6,4 85/137 V,P,D,R,T,E,N,S,K,A,H,Q 148 K LYS147:A -0.284 6 -0.598,-0.038 7,5 81/137 M,Y,N,L,F,S,K,A,H 149 F PHE148:A -1.177 9 -1.410,-1.062 9,8 81/137 R,Y,F 150 E GLU149:A -0.800 7 -1.062,-0.662 8,7 70/137 S,G,H,Q,K,E 151 P PRO150:A -0.006 5 -0.462, 0.322 6,4 59/137 T,E,L,S,Q,P,D,R 152 K LYS151:A -0.573 7 -0.953,-0.310 8,6 45/137 R,K *Below the confidence cut-off - The calculations for this site were performed on less than 6 non-gaped homologue sequences, or the confidence interval for the estimated score is equal to- or larger than- 4 color grades.