Fig 1.
Example illustrating the taxonomic structure of 6 hypothetical OTUs.
Fig 2.
Longitudinal OTU observations at l time points.
Table 1.
Description of each model compared by simulation study.
Table 2.
Estimated , Type I error and power, from 1000 replications.
Table 3.
Estimated GEE correlations under correct correlation structure, OTU independence structure and time points independence structure, compared to Pearson correlations.
Table 4.
Comparing test powers from 1P_GEE model to MTLC model when −log10 0 are replaced by 6, 5 4 and 3.
Fig 3.
Taxonomic structure of 9 OTUs.
Table 5.
Estimated effects of obesity status to OTUs and p-value.
Table 6.
Estimated correlation coefficients between time points, twins and OTUs.