Figure 1.
Schematic representation of the transformation of the AAL template into individual DTI space.
Both the T1 template and the AAL template showed in the right column are in the MNI space, with image dimensions of 181 mm×217 mm×181 mm and voxel dimensions of 1 mm×1 mm×1 mm. Both the rT1 image and the transformed AAL template overlaid on it showed in the left column are in the DTI native space of one randomly selected individual, with image dimensions of 256 mm×256 mm×45 mm and voxel dimensions of 1 mm×1 mm×3 mm. The homologous brain regions in AAL template were coded in different colors because the areas in the left and right hemispheres were considered separately.
Figure 2.
Mean map of the binary connectivity matrixes averaged across the 79 subjects.
A 90×90 symmetric matrix in which the x and y axes correspond to the regions listed in Table 1 (labeled by the abbreviations defined in Table 1) and each entry represents the percentage of subjects that have a connection between the corresponding pair of brain regions. The value of each entry ranged from 0 (black color on the map), indicating that no subject showed a connection between the corresponding pair of brain regions, to 1 (white color in the map), indicating that the two regions were connected in all subjects. The regions in the left and right hemispheres are ordered separately. Abbreviations: LH, Left Hemisphere; RH, Right Hemisphere.
Figure 3.
3D presentation of the binary connectivity matrixes averaged across the 79 subjects.
(A), (B) and (C): A 3D presentation of the network in anatomical space, in which the green points correspond to the 90 AAL regions defined in Table 1 and the lines correspond to the connection between corresponding pairs of brain regions. The colors of the lines represents the percentage of subjects that have a connection between the corresponding pair of brain regions, ranging from 0.5 (yellow color), indicating that at least half of the subjects showed a connection between the corresponding pair of brain regions, to 1 (red color), indicating that the two regions were connected in all subjects. Abbreviations: LH, Left Hemisphere; RH, Right Hemisphere.
Figure 4.
Six well-known major white matter tracts reconstructed in three randomly selected subjects.
Please note that the fiber bundles showed here may be only parts of a specific major white matter tract, rather than the entire tract.
Table 1.
Cortical and sub-cortical regions defined in the AAL template.
Table 2.
Topological properties of binary anatomical networks constructed on the individual brains of all 79 subjects using five different threshold values.
Table 3.
Topological properties including small-world indices of human brain networks in the current study and previous studies.
Table 4.
Two-sample t-test on properties of binary and weighted networks between GI and HI groups.
Figure 5.
Significant partial correlation between the total number of edges and intelligence tests scores.
was found to be positively correlated to FSIQ and PIQ.
Figure 6.
Significant partial correlation between Lp and intelligence tests scores.
In the case of binary networks, was found to be negatively correlated to FSIQ and PIQ; and in the case of weighted networks,
was found to be negatively correlated to FSIQ, PIQ and VIQ.
Figure 7.
Significant partial correlation between E_glob and intelligence tests scores.
was found to be positively correlated to FSIQ, PIQ and VIQ in both the binary and weighted networks.
Table 5.
Partial correlation between topological properties and intelligence test scores across all subjects while controlling for age and gender.
Table 6.
Brain regions that showed significant correlations between the local efficiency and intelligence test scores in binary networks across all subjects while controlling for age and gender.
Table 7.
Brain regions that showed significant correlations between the local efficiency and intelligence test scores in weighted networks across all subjects while controlling for age and gender.