Table 1.
Overview of Complex Definitions.
Figure 1.
NI = non-interaction, I = interaction. The non-interactions are calculated for each dataset before they are combined in a union or intersection dataset. The complex definition of Reactome and ortholog definitions from Ensembl are combined to find the conserved protein pairs. The interaction data of the conserved protein pairs are extracted from the datasets and the interaction conservation is calculated.
Table 2.
False Negative Rates for Different Datasets Compared to Complex Definitions.
Table 3.
Overview of PPI Datasets.
Table 4.
Conservation of Protein-Protein Interactions Defined by Reactome in Yeast.
Figure 2.
The eIF3 complexes in yeast (yellow) and human (green) are depicted in a network with similar topography relevant to the orthologs (connected by red dotted lines). Although the eIF3 complex in human has expanded compared to yeast, all yeast proteins still have orthologs in the human eIF3 complex. Modification of the complex seems to have been mainly through the acquisition of new proteins.