Figure 1.
Stability (Represented as ΔGFolding) for the True Ancestor and Reconstructed Sequences
Stability values shown for three nodes, as labelled in Figure S3: (A) shallow node, blue, (B) intermediate node, red, and (C) deep node, green. Each point represents the reconstruction of a single ancestral node in one of the 84 analysed simulations. Reconstructions were performed with MP, ML, and BI approaches. ΔGFolding values represent the average of 100 reconstructions. Points on the diagonal represent reconstructions generating accurate ancestral protein stabilities.
Figure 2.
Distribution of Errors in Reconstruction Stabilities (ΔΔG) When Reconstructions Are Made with MP (Green), ML (Red), and BI (Blue)
Figure 3.
Cumulative Distribution of Absolute Errors in Reconstruction Stabilities (|ΔΔG|)
Colour code as in Figure 2. Error with BI reconstructions are shown when averaging is performed over 100 sequence reconstructions (solid line), ten sequence reconstructions (dashed line), and a single reconstruction (dotted line).