Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection
Fig 2
Virus evolution in a given environment.
The optimal parameter combinations (p and ε) that maximize RTP are calculated for a parameter set of k = 100 and θ = 0.03 in (A). The white dot represents the optimal point of RTP in a single simulation. Using the same parameter set, 500 optima based on independent contact histories are calculated in (B). The kernel plots illustrated alongside the top and right parts are the marginal distributions of p and ε, respectively. The white dot exactly corresponds to the optimal point shown in a single simulation in (A). The white cross indicated by the black arrow corresponds to the median of optimized parameter set of p and ε based on the 500 simulation runs. In a similar manner, the parameter set of k = 0.12 and θ = 10 is used to calculate the optimal parameter combinations (p and ε) in (C). Using the same parameter sets, 500 evolutionary consequences for independently drawn contact histories are shown in (D). The white dot and white cross correspond to the optimal point of the parameter set and the median point, respectively.