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Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm

Fig 10

CaV+BK (A) and CatSper+NHE (B) modules predict distinctive responses to manipulation of membrane potential.

The graphs show the numerical solutions of the indicated variables under the reference parameters as in Figs 4 and 6. The normal resting state is perturbed (in the absence of SAP, S = 0 nM) by setting the membrane potential to a higher value (V = 0 mV) at time t = 0 for a short period of 0.25 s (indicated by the two vertical dashed lines).

Fig 10

doi: https://doi.org/10.1371/journal.pcbi.1007605.g010