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Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm

Fig 4

Dynamics of the model featuring the CaV+BK module.

The state space is {S, RF, RH, RL, G, , , V, , , , C}. As in Fig 2, the initial stimulus is S(0) = 25 nM is used. From top to bottom, the numerical solutions obtained with the parameters listed in Table 2 are shown for: [Ca2+]i (C) together with cGMP concentration (G), open channel fractions, ionic currents and membrane potential. The ionic currents are displayed in current densities (left axis) and as current normalised by capacitance (right axis).

Fig 4