Advertisement

< Back to Article

Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation

Fig 4

Effect matrix of pathogen-specific gene effect strengths ρvg.

The 25 strongest hits when sorting by absolute effect sizes γg are shown. Every column shows one virus and every row represents the effect size of a gene knockdown on the specific virus ρvg. For some of the genes, such as DYRK1B, PKN3, CDK6 or CSNK2B, the knockdown has an either all-positive, or all-negative effect on the viral replication cycle.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1007587.g004