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CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data

Fig 1

Schematic of the CDSeq approach.

Heterogeneous samples consist of different cell types. The bulk RNA-Seq profile represents a weighted average of the expression profiles of the constituent cell types. CDSeq takes as input the bulk RNA-Seq data for a collection of samples and performs complete deconvolution that outputs estimates of both the cell-type-specific expression profiles and the cell-type proportions for each sample. This Figure depicts a simple scenario of six biological samples comprising four cell types, each with gene expression measurements on eight genes.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1007510.g001