CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data
Heterogeneous samples consist of different cell types. The bulk RNA-Seq profile represents a weighted average of the expression profiles of the constituent cell types. CDSeq takes as input the bulk RNA-Seq data for a collection of samples and performs complete deconvolution that outputs estimates of both the cell-type-specific expression profiles and the cell-type proportions for each sample. This Figure depicts a simple scenario of six biological samples comprising four cell types, each with gene expression measurements on eight genes.