Between-tumor and within-tumor heterogeneity in invasive potential
(A) Between-tumor tests between organoid size and invasiveness remain significant. (p = 0.008). (B) The within-tumor test shows a highly significant association (9.8 × 10−52) for a linear model (dashed blue line) between invasiveness and rank-transformed organoid area. Organoids are colored according to extreme tail membership. (C) Tests performed using organoids restricted to extreme tails are also highly significant (solid line), as are pooled tests for association of area with invasiveness.