Between-tumor and within-tumor heterogeneity in invasive potential
Each boxplot represents the distribution of invasion scores for organoids generated from a single tumor, with tumors ordered from left to right by median organoid invasiveness. The boxplot for each tumor indicates the median value (red bar), lower and upper quartile values (box extent), and outliers as individual points. (A) Distributions generated using invasion on an arithmetic scale are asymmetric, with the median closer to the first quartile and a larger upper tail. The interquartile range increases substantially with the median invasiveness. (B) Distributions generated using invasion on a logarithmic scale are more symmetric, with the median approximately halfway between the first and third quartile. The interquartile range increases less with the median.