The role of intracellular interactions in the collective polarization of tissues and its interplay with cellular geometry
Since Fz and Vang appear on an equal footing in the model, the background mutants are only shown for Vang− tissues. The corresponding phenotypes in fz− background, are obtained by replacing Fz and Vang and flipping the arrows. The colors of the background and clones are chosen as follows: blue and green represent Fz and Vang, respectively. Together, Fz and Vang make the cyan background in the first row. Lack of either one is represented by the complementary color. The left panel of the third row shows mutants lacking cytoplasmic proteins in ds− background. Red arrows must be interpreted as the directions of the polarity distortion measured with respect to the wild-type polarity; not the direction of the resulting polarity (see S7 Fig for further clarification). The thickness and length of an arrow indicate the magnitude and spatial extension of non-autonomy, respectively. The right two panels of the third row correspond to the geometrically disordered clones, with and without global graded cues. In this case the arrows show the resulting polarization fields.