EAGLE: An algorithm that utilizes a small number of genomic features to predict tissue/cell type-specific enhancer-gene interactions
(A) Performance of EAGLE model in the mouse by self-testing and cross-sample test. (B) Enhancer-target relationships across 35 representative cell types in the mouse. The EAGLE model in the mouse was trained in the lung. In the heatmap, each row represents an enhancer-target interaction, while each column is one particular cell type. The color represents the prediction confidence score for this interaction. On average, 95,723 relationships were identified in each cell type. Majority of the relationships were tissue-specific.