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The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model

Fig 11

Simulation results for cell migration through an isotropic viscoelastic ECM (without any nonlinear elastic springs).

Results for cells with 1 (blue, n = 17), 2 (red, n = 17), 3 (yellow, n = 17) or 4 (magenta, n = 17) simultaneous protrusions. (A) Cell shapes after 6 hours of migration. The black circle indicates the ECM boundary with a radius of 150 μm. (B) Cell paths representing the cell center of mass displacement during 6 hours. (C) Absolute cell migration velocity (vmigr,abs, cell position after 6 hours minus initial cell position, divided by 6 hours) and migration velocity along cell path (vmigr,path, total path length divided by 6 hours). (D) Total number of protrusions (#prot) as function of the prescribed number of simultaneous protrusions (nprot) and MSD as function of time lag τ (log-log plot), where α = 1 represents the slope of the MSD for a random walk. Horizontal bars indicate a significant difference between outcome parameter values of two groups of 12 simulations, calculated by means of the unpaired two-sample t-test. Statistical significance: * p<0.05, ** p<0.01, *** p<0.005. Outliers shown in gray.

Fig 11