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The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model

Fig 7

Results of a cell migration model parameter study for ECM stiffness and cell strength.

Box plots of average absolute cell migration velocity (vmigr,abs), total number of protrusions (#prot) and protrusion lifetime (τprot) as function of 2 different model parameters: ECM stiffness (EECM, first row) and cell strength (reference actomyosin contractile force Fam, second row). For each parameter 5 different parameter values were evaluated and for each parameter value 12 simulations were run. Horizontal bars indicate a significant difference between outcome parameter values of two groups of 12 simulations, calculated by means of the unpaired two-sample t-test. Statistical significance: * p<0.05, ** p<0.01, *** p<0.005. Outliers shown in gray.

Fig 7