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The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model

Fig 5

Cell shapes and pathways for different ECM stiffnesses.

(A) Cell shapes after 6 hours of migration and (B) cell migration paths for cell migration through an ECM with ECM stiffness of 50, 100, 200, 300 and 400 Pa (left to right). The black circle indicates the ECM boundary with a radius of 150 μm. For each ECM stiffness 12 simulations were run.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1007250.g005