PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems
By modifying the worker cells in the previous example (Fig 7) to move up hypoxic gradients (along −∇pO2) and drop their cargo in hypoxic zones, we can deliver cargo to a growing tumor. In this example, the cargo cells secrete a therapeutic that induces apoptosis in nearby tumor cells, leading to partial tumor regression. Bar: 200 μm. A video is available at S6 Video.