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PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

Fig 8

Anti-cancer “biorobots” example.

By modifying the worker cells in the previous example (Fig 7) to move up hypoxic gradients (along −∇pO2) and drop their cargo in hypoxic zones, we can deliver cargo to a growing tumor. In this example, the cargo cells secrete a therapeutic that induces apoptosis in nearby tumor cells, leading to partial tumor regression. Bar: 200 μm. A video is available at S6 Video.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1005991.g008