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PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

Fig 7

“Biorobots” example.

Director cells (green) release a chemoattractant c1 to guide worker cells (red). Cargo cells (blue) release a separate chemoattractant c2. Unadhered worker cells chemotax towards ∇c2, test for contact with cargo cells, form adhesive bonds, and then pull them towards the directors by following ∇c1. If c1 exceeds a threshold, the worker cells release the cargo and return to seek more cargo cells, repeating the cycle. Bar: 200 μm. A video is available at S5 Video.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1005991.g007