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PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

Fig 1

PhysiCell and multiple time scales.

PhysiCell uses BioFVM to update the microenvironment at the short green tick marks, corresponding to Δtdiff. It updates cell mechanics (including cell position) less frequently at the medium black tick marks (Δtmech), and it runs the cell volume and cycle/death models least frequently at the long red tick marks (Δtcell). Note that the time steps shown are for illustrative purpose; the default step sizes are given in Time steps.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1005991.g001