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A network diffusion approach to inferring sample-specific function reveals functional changes associated with breast cancer

Fig 1

Overall approach.

The reference gene is depicted by black circle. The initial static global PIN is projected onto normal and cancer samples based on gene expression, and each function (red and green) are diffused through each PIN. In this case, the reference gene is assigned green function in normal and red function in cancer, i.e., the gene gained red and lost the green function in cancer.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1005793.g001