Structural host-microbiota interaction networks
(a) High-resolution metaorganism network where grey nodes represent host proteins, red nodes microbial proteins, black edges host PPIs, and red edges HMIs. If an exogenous interface–HMI–(red edges) overlaps endogenous ones, it can abolish the endogenous PPI. If the exogenous and endogenous interfaces do not overlap, then the HMI does not disrupt the endogenous PPI. Without 3D structure knowledge of PPIs and HMIs, we cannot infer whether the interfaces overlap or not. (b) Zoom-in views of blue boxes show whether the interfaces overlap. (c) 3D representations of the interactions shown in part (b). Above diagram shows the superimposed view of 4mi8:AC and 2p1l:AB where Gamma Herpesvirus vBcl2 (red) and human Bcl-XL (green) binds to the same site on human Beclin-1 (grey). Here, an exogenous interface mimics an endogenous interface. Below diagram shows the superimposed view of 1f5q:AB and 1buh:AB, where Gama Herpesvirus Cyclin (red) and human CKS1 (green) bind to distinct interfaces on human CDK2 (grey).