Polarization and migration in the zebrafish posterior lateral line system
The FGF receptor blocker SU5402 increases the size of the WntR activity domain in a dose-dependent manner (lef1 used as a marker). The size of the lef1 domain has been normalized relative to the size of the whole PLLP. A Linear regression analysis resulted in y = 0.2005x + 0.515. A one-way ANOVA reveals that the slope is significantly non-zero (0.2005 ± 0.03012). The 95% confidence interval for the slope is 0.1405—0.2605, with R2 = 0.3536, and P < 0.0001. These results validate the findings of our model.