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Polarization and migration in the zebrafish posterior lateral line system

Fig 2

Ligand-receptor dynamics forms a basis for our model.

FGF or Wnt receptors are synthesized, presented on the cell surface, and, after binding to ligand, phosphorylated and internalized by endocytosis. Here we assume that ligand-receptor binding is rapid on the timescale of such receptor dynamics, so that we can approximate the bound receptor level by Eq (3).

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1005451.g002