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Mindboggling morphometry of human brains

Fig 7

Cortical fold extraction and sulcus segmentation.

Top left: Lateral view of the left hemisphere of a brain with folds labeled red. Mindboggle extracts cortical surface folds based on a depth threshold that it computes from the distribution of travel depth values. Bottom left: individually colored folds from the same brain. The red surface shows that folds can be broadly connected, depending on the depth threshold, and therefore do not map one-to-one to anatomical region labels. Top right: The same folds with individually colored anatomical labels. These labels can be automatically or manually assigned (as in the case of this Mindboggle-101 subject). Bottom right: Individually colored sulci. Mindboggle uses the anatomical labels to segment folds into sulci, defined as folded portions of cortex whose opposing banks are labeled with sulcus label pairs in the DKT labeling protocol [22]. Each label pair is unique to one sulcus and represents a boundary between two adjacent gyri, so sulcus labels are useful to establish correspondences across brains. Portions of folds that are missing in the bottom right panel compared to the top right panel are not defined as sulci by the DKT labeling protocol.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1005350.g007