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Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data

Fig 8

Comparison of ISD to existing methods for chromosome structure inference from single-cell Hi-C data.

ShRec3D, MBO and the simulated annealing procedure (SA) by Nagano et al. (two versions of SA were tested: a long version based on the default annealing protocol and a short version with ten-fold faster annealing). (A): Accuracy (RMSD to ground truth) achieved with all four methods. (B): Precision (spread of structural ensemble) for MBO, SA and ISD (ShRec3D produces only a single model, therefore it is not possible to assess the precision of the ShRec3D model). Both accuracy and precision are quantified by RMSDs and increase when the RMSDs decrease.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1005292.g008