Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data
(A) The chromatin fiber is composed of beads representing 500 kb of chromatin. Every bead is modeled as a spherical shape of size a. Configurations with overlapping beads are penalized using a nonbonded force field accounting for volume exclusion. The beads are arranged as a linear chain where the spacing between the beads is chosen such that two neighboring beads touch each other in the equilibrium configuration. (B) Effective potential between consecutive beads along the chromatin fiber. The dashed vertical line indicates the size of the spherical bead a = 430 nm.