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Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data

Fig 5

X-chromosome structure at 50 kb resolution.

(A) Representative structure of the X chromosome at 50 kb resolution where the tube thickness and color encodes the local packing density (dense packing: red, thick; low packing: blue, thin). (B) Representative structure of the X chromosome with beads involved in trans-chromosomal contacts highlighted as red spheres. (C) Contact probability between beads in the ISD ensemble as a function of the genomic distance s. Predictions made by various polymer models are shown as dashed lines: s−3/2 ideal chain/equilibrium globule, s−1 fractal globule.

Fig 5