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Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

Fig 6

Correlation analysis of transcriptional changes in hepatocyte cell culture.

Co-expression network analysis of expression changes when comparing mRNA between cultured hepatocytes vs. liver or immediately after hepatocyte isolation (vs. 0hrs RPH). Cells are colored on the Pearson correlation coefficient R obtained by comparing module scores for two conditions. Conditions are clustered to group those showing similar scores across 415 modules, revealing broad similarity following 24–48 hours in culture for RPH, HPH, MPH and HepG2 cells from various sources.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1004847.g006