Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes
Pairs of experiments involving the same drug are compared via the Pearson R and percent overlap metrics, and average concordance is calculated between A) TG rat liver vs. TG RPH, B) TG RPH vs. TG HPH and C) TG HPH vs. GEO HepG2. The data source shown in italics is the reference for each comparison, to which experiments from the other source are compared. For A), only the optimistic comparison is performed because dose / time are not comparable in vivo vs in vitro. Refer to Fig 2 caption for details.