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Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

Fig 3

Comparison of in vitro vs. in vivo treatment effects for azathioprine.

Transcriptional effects after treatment of rat primary hepatocytes with 4 μM azathioprine for 24 hours were compared to 24 different in vivo azathioprine experiments in rat liver. The low, medium and high in vivo doses are denoted with separate lines, and concordance is assessed vs. time using 6 analysis methods (two concordance metrics and genes / GSA / module analysis). The circled point denotes the most concordant in vivo dose / time condition for each of the 6 analysis methods.

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1004847.g003