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A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation

Table 3

Apparent Cas9 binding energies to canonical and non-canonical PAM sites (kcal/mol).

The energies are average values of all combinations in the first and fifth positions. (blue) The canonical PAM sites (NGGN) are bolded. N.B: no statistically significant binding. nt: nucleotide.

Table 3