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An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

Fig 8

Roles of the miR34a-Snail and miR200-Zeb1 mutual inhibition loops in the four-state EMT system.

Comparison of removing miR34a-Snail mutual inhibition (left column), miR200-Zeb1 mutual inhibition (middle column), or both (right column) on the four phenotypes. Each subplot is a two-parameter bifurcation diagram similar to Fig 6A. Subplots in each column highlight the various phenotypes in one condition. Shaded areas are highlighted phenotypes. Colors of the shading correspond to the colored labels on the right.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1004569.g008