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A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

Fig 5

Mutations in TP53 interface predict patient's outcomes.

a) Our analysis identified the interface between TP53 and SV40 (shown in gray and orange respectively) as strongly enriched in mutations (panel c). b) This interface is the same as the one that TP53 uses to interact with other TP53 molecules (shown in dark blue) and DNA (shown in light blue). d) Breast cancer patients with mutations in this interface (shown in red) have worse outcomes than those with other or no TP53 mutations (shown in blue and red respectively).

Fig 5