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A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

Fig 3

Network properties of interface-driver genes.

a) Most genes identified by e-Driver (shown in red) cluster together with other cancer driver genes (shown in light blue). Genes are sized according to their number of interactions (genes with more interactions are bigger and vice versa). Note that genes identified by e-Driver that are also known drivers (shown in purple) tend to have many interactions with other cancer genes. Edges are weighted according to the number of networks where they can be identified, with thicker edges being found in more networks, and vice versa. b) Interface driver genes have similar network properties when compared to known cancer driver genes. Both groups of genes have higher degree (left) and betweenness (right) than the rest of the genes in the genome. c) Known drivers identified by e-Driver (in purple) have higher degree and betweenness than other drivers (known-in blue- or predicted-in red-) or the rest of the genes in the genome (shown in light gray). Statistics in panels (b) and (c) are based on network properties from the network “Vidal merged”. The statistics for the all networks are in Tables AI and AJ in S1 Table.

Fig 3