Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding
A) Protein structures of DapA and TIM, highlighting their similar TIM barrel topology. B) Free energy contour map of TIM as a function of RMSD and ρ at 400 K as a control is depicted. The color bar denotes the Gibbs free energy in kJ/mol. The inset within the map shows distribution of fraction of native contacts, Q.