Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes
Ohnolog association to cancer and diseases in human.
(A) Gene Ontology enrichment for four amniote ohnolog datasets from the relaxed criteria. From top to bottom, the top 25 enriched GO terms, sorted on the basis of average rank across the four genomes. Bubble sizes are proportional to the rank (p-value) of the term for each genome. (B) Ohnolog association to cancer and genetic diseases in human. Ohnolog enrichment is especially significant for core cancer genes, autosomal dominant disease genes and genes with autoinhibitory protein folds, see text, in agreement with earlier reports [5, 6, 15].