Linear Motif-Mediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks
(a) Topological modularity, MPPI, in nine representative eukaryotic species. (b) A schematic showing how increased complexity is associated with MPPI. (c) Network modularity (MDLI/DDI) in nine representative eukaryotic species. (d) A schematic showing how DLIs are associated with increased MDLI/DDI. (e) The evolution of ‘cell-cell adhesion’ and ‘leukocyte migration’ groups is shown as an example.