Human Dominant Disease Genes Are Enriched in Paralogs Originating from Whole Genome Duplication
Distributions of WGD, SSD, and singletons for human orthologs of mouse genes (A) tested for essentiality in mouse , (B) found to be essential in mouse, and (C and D) after removing dominant disease genes, oncogenes, and genes with dominant negative mutations or autoinhibitory folds .
(*) corresponds to small deviations (10−3<p<0.05, FE test) from the references in (A). Note that human orthologs of essential genes in mouse do not show any significant deviations in WGD, SSD, or singleton contents (p>0.05, FE test) once dominant disease genes, oncogenes, and genes with dominant negative mutations or autoinhibitory folds have been removed. Yet, taking into account the age of SSD duplicates reveals a relative lack of recent SSD genes in essential genes (see text).