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Network Analysis of Breast Cancer Progression and Reversal Using a Tree-Evolving Network Algorithm

Figure 5

Diseases associated with the genes in the differential network of each breast cell state.

(A) S1; (B) T4; (C) the EGFR/ITGB1-T4R group; (D) the PI3K/MAPKK-T4R group; and (E) the MMP-T4R group. In each plot, the differential network for the corresponding cell state is shown. Nodes represent genes; edges represent interaction of the genes. Diseases associated with the genes in the network (unadjusted p-values<0.05) are color-coded and shown on the right; genes associated with a certain disease are also colored based on the color code for the corresponding disease. An asterisk indicates a disease that is significantly enriched in the corresponding differential network.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1003713.g005