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Comparative Analysis of Human Tissue Interactomes Reveals Factors Leading to Tissue-Specific Manifestation of Hereditary Diseases

Figure 1

The construction of 16 human tissue interactomes by integrating data of tissue expression with data of PPIs.

Data of expression per tissue according to DNA microarray (GNF, [12]), protein abundance (HPA, [14]), and RNA-sequencing (RNA-seq, [15]) were consolidated into 16 main tissues. In parallel, experimentally detected PPIs were united from BIOGRID [16], DIP [17], IntAct [18] and MINT [19] to form a global human interactome. Tissue interactomes were then constructed by filtering the global interactome per tissue to contain only PPIs in which both pair-mates were found to be expressed within the tissue.

Figure 1