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Quantitative Protein Localization Signatures Reveal an Association between Spatial and Functional Divergences of Proteins

Figure 6

Large portion of WGD duplicates now have diverged localization patterns.

Distributions of (A) P-profile dissimilarity scores (dp), (B) ratios of shared compartments, and (C) numbers of compartments assigned to WGD duplicate (red) and random non-duplicate (black) pairs (M = medians, μ = means of the distributions; two-sided permutation tests for differences in medians or means.) Protein pairs with dp≥10th-percentile of non-duplicate pairs are referred to as “dissimilarly localized” (DL) pairs, or otherwise as “similarly localized” (SL) pairs. (D) Ratios of DL duplicate pairs in the ten biological processes with the highest numbers of duplicate pairs (parentheses = numbers of duplicate pairs with P-profiles, red dashed line = DL-duplicate ratio for all duplicate pairs.) (E) Example images from the UCSF dataset [1] showing DL duplicate pairs with different dp values. The intensity of each image has been scaled to the same range. The molecular functions of the duplicates are also shown if they are known.

Figure 6