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Quantitative Protein Localization Signatures Reveal an Association between Spatial and Functional Divergences of Proteins

Figure 5

Duplicates with different divergence times have significantly different spatial divergence levels but similar numbers of occupied subcellular compartments.

(A) We used a phylogeny of orhtologous gene groups estimated for Ascomycota fungi [37] (inset = number of S. cerevisiae duplicates that we could traced to their originating ancestors without any loss event; blue = “old” duplicates; red = “young” duplicates; WGD = whole genome duplication.) The (B) mean P-profile dissimilarity scores (dp), (C) shared compartment ratios, (D) mean protein expression levels, and (E) total numbers of occupied compartments for duplicates with different divergence times (dashed black vertical line = division between “young” and “old” duplicates; error bars = standard errors; red/blue line = mean values for the young or old duplicates, respectively; P-values from two-sided t-tests between young and old duplicates.) (F) Results from linear regression modeling of dp and shared compartment ratio using divergence age and protein expression level as factors (T = T-statistics of the factors; F = F-statistics for the analyses of variance (ANOVA) between two regression models with different factors; R2 = squared correlation coefficients between the actual and predicted values of dp or shared compartment ratio.)

Figure 5