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Metabolic Constraint-Based Refinement of Transcriptional Regulatory Networks

Figure 3

Iterative approach for network refinement and phenotype prediction.

By using an iterative approach, we increased the comprehensiveness of the integrated network model by adding new interactions (Network III) and iteratively refining the model using GEMINI. This process enriched the fraction of validated interactions in the network (shown in red) and improved the predictive ability of the integrated network model.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1003370.g003