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Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin

Figure 6

Crystallographic data of Pro-Leu-Ser-Phe-Leu-Val binding to a region on the surface of LSD1/CoREST AOD.

The peptide (green) and LSD1 (brown) are highlighted (nitrogen atoms: blue; oxygen atoms: red). The unbiased 2Fo-Fc electron density map (contoured at 1.2 σ level) was calculated prior to inclusion of the peptide in the refinement. Residue Pro1 of the bound peptide was not visible in the electron density and, therefore, was not included in the model. See also Table 1 and Figure 8, region D.

Figure 6