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Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin

Figure 5

LSD1/CoREST crystal contacts.

SiteMap sites on LSD1/CoREST overlap with crystal contact regions. Panel A shows the crystal-packing interactions of three LSD1/CoREST molecules represented as red, blue, and grey opaque surfaces. In Panels B and C LSD1/CoREST are represented as transparent surfaces and SiteMap sites are colored surfaces to correspond with the unit in Panel A, e.g. the blue SiteMap sites in Panel B originate from the blue LSD1/CoREST in Panel A.

Figure 5